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Friday, December 3 • 4:00pm - 4:30pm
Keynote 4 - Mapping and Navigating the Human Regulatory Genome - Wouter Meuleman, PhD

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Principal Investigator
Altius Institute for Biomedical Sciences
United States

Biography (web)

Mapping and Navigating the Human Regulatory Genome

This year marks the 20 year anniversary of the sequencing of the human genome in 2001. Since then, many large-scale data generation and analysis efforts have built upon this work by producing genome-wide maps and annotations. Most recently, we have systematically delineated and annotated accessible DNA elements in the human genome, by integrating more than 700 genome-wide maps of chromatin accessibility resulting in a single high definition annotation. Additionally, we have developed simple information-theoretic metrics (epilogos) to integrate chromatin state data across nearly 1,000 cell types and states. Despite these and many other efforts, systems to efficiently navigate genomic maps at scale have remained lacking. At the same time, consumer-facing web businesses such as Zillow, Spotify, and Amazon have long understood the value of learning from patterns collected across large corpora of data, to better serve customers, maximize investment returns and prioritize future directions. This gap between current practice in genomics and ultimate potential forms the overarching motivation for our work. We are coupling massive amounts of genomics data to powerful recommendation engines and related machine learning approaches to generate insights not otherwise obtained. These ideas represent an essential and inevitable transition towards “augmented genomics”, a new field in which the work of genome scientists is supplemented - not replaced! - by data-driven machine intelligence.

avatar for Wouter Meuleman

Wouter Meuleman

Principal Investigator, Altius Institute for Biomedical Sciences
Wouter Meuleman’s research focuses on how the regulatory genome is organized, and what the functional implications of this organization are. His long term research goal is to make “augmented genomics” a reality: a new field in which the work of genome scientists is supplemented... Read More →

Friday December 3, 2021 4:00pm - 4:30pm MST
Ballroom Salon 1