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Friday, December 3 • 11:05am - 11:15am
OP 24 - A Tale of Two Systems: Influenza and COVID-19

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A Tale of Two Systems: Influenza and COVID-19

Presenting Author: Christian Forst, Icahn School of Medicine at Mount Sinai, New York, NY

Abstract: The ongoing SARS-CoV-2 pandemic poses a threat to public health and economy, thus urges the scientific community to join efforts in the search of cures. Meanwhile, both influenza and COVID-19 are respiratory diseases caused by airborne RNA viruses, cause massive interferon response as a first line of defense of the host against the infection, and scientific advances from studying influenza infection have potentials to benefit the search of cure for SARS-CoV-2 infections. Indeed, increasing evidences show co-infections of influenza and SARS-CoV-2 were common during the pandemic and pose greater risk of developing poor outcomes, and influenza A pre-infection promotes infectivity of SARS-CoV-2 potentially via increasing ACE2 expressions. Here we present a comprehensive, multi-scale network analysis of the systems response to the virus. We have developed methods that integrate single-cell and bulk transcriptomic data. These integrated data were further related to clinical outcomes. By this approach we were able to identify cell-population specific key-regulators and host-processes that are hijacked by the virus for its advantage and that contribute to the severity of these infectious diseases.

Friday December 3, 2021 11:05am - 11:15am MST
Ballroom Salon 1